Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines.

Abstract

A series of 2-substituted 1,2-dihydro-3-phenyl-1-(trichloromethyl)benzo[b][1,6]naphthyridines were synthesized and their in vitro antiproliferative activities were examined against human solid tumor cell lines and relevant strains of bacteria and Candida. The compounds induced considerably growth inhibition in all cancer cell lines, whilst showed inactive against microbial strains. Furthermore, we found analog 2-ethoxy-1H-pyrano[4,3-b]quinoline as selective inhibitor of microbial strains.

DOI: 10.1016/j.bmcl.2010.01.112

Cite this paper

@article{Rudys2010AntiproliferativeAO, title={Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines.}, author={Simonas Rudys and Carla R{\'i}os-Luci and Eduardo P{\'e}rez-Roth and Inga {\vC}ikotienė and Jos{\'e} M. Padr{\'o}n}, journal={Bioorganic & medicinal chemistry letters}, year={2010}, volume={20 5}, pages={1504-6} }