Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes.

  title={Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes.},
  author={George Awuku Asare and Dan K. Afriyie and Robert Amadu Ngala and Harry Abutiate and Derek Amartey Doku and Seidu Abdulai Mahmood and Habibur Rahman},
  journal={Integrative cancer therapies},
  volume={14 1},
BACKGROUND Annona muricata L. has been reported to possess antitumor and antiproliferative properties. Not much work has been done on its effect on BPH-1 cell lines, and no in vivo studies targeting the prostate organ exist. The study determined the effect of A muricata on human BPH-1 cells and prostate organ. METHODS The MTT assay was performed on BPH-1 cells using the aqueous leaf extract of A muricata. Cells (1 × 10(5) per well) were challenged with 0.5, 1.0, and 1.5 mg/mL extract for 24… CONTINUE READING
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