Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors.

@article{Cops2008AntiproliferativeAO,
  title={Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors.},
  author={Elisa J Cops and Tina Bianco-Miotto and Nicole L. Moore and Christine L. Clarke and Stephen N. Birrell and Lisa M Butler and Wayne D Tilley},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2008},
  volume={110 3-5},
  pages={236-43}
}
Androgen signaling, mediated by the androgen receptor (AR), is a critical factor influencing growth of normal and malignant breast cells. Given the increasing use of exogenous androgens in women, a better understanding of androgen action in the breast is essential. This study compared the effects of 5alpha-dihydrotestosterone (DHT) and a synthetic androgen, mibolerone, on estradiol (E(2))-induced proliferation of breast cancer cells. DHT modestly inhibited E(2)-induced proliferation and… CONTINUE READING
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