Antiproliferative actions of growth hormone-releasing hormone antagonists on MiaPaCa-2 human pancreatic cancer cells involve cAMP independent pathways.

Abstract

We evaluated the effects of GHRH antagonists on the proliferation of MiaPaCa-2 human pancreatic cancer cells and cAMP signaling in vitro. GHRH antagonists inhibited the proliferation of MiaPaCa-2 cells in vitro in a dose-dependent way and caused a significant elevation in cAMP production. In a superfusion system, short-term exposure of the cells to GHRH… (More)

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@article{Rksi2001AntiproliferativeAO, title={Antiproliferative actions of growth hormone-releasing hormone antagonists on MiaPaCa-2 human pancreatic cancer cells involve cAMP independent pathways.}, author={Zolt{\'a}n R{\'e}k{\'a}si and Judit Varga and Andrew V Schally and Arthur Plonowski and G{\'a}bor Halmos and Bal{\'a}zs Csernus and Patricia Armatis and Kirsten de Groot}, journal={Peptides}, year={2001}, volume={22 6}, pages={879-86} }