Antiproliferative Effects of 1α-OH-vitD3 in Malignant Melanoma: Potential Therapeutic implications

  title={Antiproliferative Effects of 1α-OH-vitD3 in Malignant Melanoma: Potential Therapeutic implications},
  author={Lucia Spath and Alessandra Ulivieri and Luca Lavra and Laura Fidanza and Marta Carlesimo and Maria Giubettini and Alessandra Narcisi and Emidio Luciani and Barbara Bucci and Daniela Pisani and Salvatore Sciacchitano and Armando Bartolazzi},
  booktitle={Scientific reports},
Early detection and surgery represent the mainstay of treatment for superficial melanoma, but for high risk lesions (Breslow's thickness >0.75 mm) an effective adjuvant therapy is lacking. Vitamin D insufficiency plays a relevant role in cancer biology. The biological effects of 1α hydroxycholecalciferol on experimental melanoma models were investigated. 105 melanoma patients were checked for 25-hydroxycholecalciferol (circulating vitamin D) serum levels. Human derived melanoma cell lines and… CONTINUE READING
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