Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression

@article{Belin2009AntiproliferativeEO,
  title={Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression},
  author={Sophie Belin and Ferdinand Kaya and Ghislaine Duisit and Sarah Giacometti and Joseph Ciccolini and Michel Font{\'e}s},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={396 - 401}
}
BACKGROUND Ascorbic acid (AA), or Vitamin C, is most well known as a nutritional supplement with antioxidant properties. Recently, we demonstrated that high concentrations of AA act on PMP22 gene expression and partially correct the Charcot-Marie-Tooth disease phenotype in a mouse model. This is due to the capacity of AA, but not other antioxidants, to down-modulate cAMP intracellular concentration by a competitive inhibition of the adenylate cyclase enzymatic activity. Because of the critical… CONTINUE READING

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