Antiprogestins RU486 and ZK299 suppress basal and LHRH-stimulated FSH and LH secretion at pituitary level in the rat in an oestrous cycle stage-dependent manner.

@article{Bellido1999AntiprogestinsRA,
  title={Antiprogestins RU486 and ZK299 suppress basal and LHRH-stimulated FSH and LH secretion at pituitary level in the rat in an oestrous cycle stage-dependent manner.},
  author={Carmina Bellido and Dolores Gonzalez and Rafaela Aguilar and Jos{\'e} Eugenio S{\'a}nchez-Criado},
  journal={The Journal of endocrinology},
  year={1999},
  volume={163 1},
  pages={79-85}
}
We have previously shown that administration of antiprogestin (AP) type II RU486 to ovariectomized (OVX) rats on the morning of pro-oestrus decreases the magnitude of preovulatory gonadotrophin surge. This suggests that the effect of RU486 on LHRH-dependent gonadotrophin release may be independent of its ability to block progesterone actions. The aim of the present research was to study the possible site of RU486 action and to determine whether the gonadotrophin suppressive effect of APs RU486… CONTINUE READING