Antipneumococcal activity of DW-224a, a new quinolone, compared to those of eight other agents.

@article{KosowskaShick2006AntipneumococcalAO,
  title={Antipneumococcal activity of DW-224a, a new quinolone, compared to those of eight other agents.},
  author={Klaudia M Kosowska-Shick and Kim L Credito and Glenn A. Pankuch and Gengrong Lin and B{\"u}lent Bozdoğan and Pamela Mcghee and Bonifacio E Dewasse and Dong-Rack Choi and Jei Man Ryu and Peter C. Appelbaum},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 6},
  pages={2064-71}
}
DW-224a is a new broad-spectrum quinolone with excellent antipneumococcal activity. Agar dilution MIC was used to test the activity of DW-224a compared to those of penicillin, ciprofloxacin, levofloxacin, gatifloxacin, moxifloxacin, gemifloxacin, amoxicillin-clavulanate, cefuroxime, and azithromycin against 353 quinolone-susceptible pneumococci. The MICs of 29 quinolone-resistant pneumococci with defined quinolone resistance mechanisms against seven quinolones and an efflux mechanism were also… CONTINUE READING

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