Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor.

@article{Simon1993AntiplateletPO,
  title={Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor.},
  author={Daniel I. Simon and Jonathan S. Stamler and O Jaraki and John F. Keaney and John Andrew Osborne and Stacy A. Francis and David J. Singel and Joseph Loscalzo},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1993},
  volume={13 6},
  pages={
          791-9
        }
}
S-nitrosothiols may serve as carriers in the mechanism of action of endothelium-derived relaxing factor (EDRF) by stabilizing the labile nitric oxide (NO) radical from inactivation by reactive species in the physiological milieu and by delivering NO to the heme activator site of guanylyl cyclase. Low-molecular-weight thiols, such as cysteine and glutathione, form S-nitrosothiol adducts with vasodilatory and antiplatelet properties, and protein thiols can interact in the presence of NO and/or… CONTINUE READING

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