Antiplatelet effect of the anaesthetic drug propofol: influence of red blood cells and leucocytes

@article{DeLaCruz1999AntiplateletEO,
  title={Antiplatelet effect of the anaesthetic drug propofol: influence of red blood cells and leucocytes},
  author={Jos{\'e} Pedro De La Cruz and M. V. Paez and Jos{\'e} Antonio Carmona and Felipe S{\'a}nchez de la Cuesta},
  journal={British Journal of Pharmacology},
  year={1999},
  volume={128}
}
The present study was designed to investigate the mechanism of the antiplatelet action of the anaesthetic propofol in vitro. Human whole blood was incubated with different concentrations of propofol and its solvent Intralipid®. We determined, platelet aggregometry in whole blood, platelet‐enriched plasma (PRP), PRP plus red blood cells (RBC), and PRP plus leucocytes (LC); platelet production of thromboxane B2 (TxB2), ATP release by platelet dense granules, adenosine uptake by RBC, intraplatelet… Expand
The Effect of Propofol on the Interaction of Platelets with Leukocytes and Erythrocytes in Surgical Patients
TLDR
Propofol inhibited platelet aggregation in surgical patients mainly as a result of the inhibition of Tx synthesis and the increase in nitric oxide production. Expand
In vitro effect of clinical propofol concentrations on platelet aggregation.
TLDR
It is suggested that propofol at concentrations required for sedation and general anesthesia has no inhibitory effect on platelet aggregation after 3 h of incubation. Expand
Effects of propofol on the leukocyte nitric oxide pathway: in vitro and ex vivo studies in surgical patients
TLDR
It is concluded that propofol stimulated constitutive NO production and inhibited inducible NO production, possibly by curtailing the stimulation of iNOS by inflammatory mediators in surgical patients. Expand
The Effects of Propofol-remifentanil Total Intravenous Anesthesia on Platelet Function
TLDR
Total intravenous anesthesia with propofol and remifentanil significantly reduced collagen-induced platelet aggregation intraoperatively, while inhalation anesthesia with sevoflurane did not reduce collagen-or ADP-induced Platelet aggregation at all. Expand
Intraoperative changes in platelet function in relation to moderate haemorrhage.
TLDR
Platelet function, as measured by impedance aggregometry, changes in response to a surgical stimulus involving blood loss, and the potential of manipulating them for therapeutic purposes, remains to be elucidated. Expand
Approach to the Assessment of Platelet Function: Comparison between Optical-based Platelet-rich Plasma and Impedance-based Whole Blood Platelet Aggregation Methods
TLDR
The WB impedance aggregation methodology has many advantages over the optical PRP assay for the assessment of the hyperactive platelet syndrome and the effects of anti-platelet drugs. Expand
Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats
TLDR
This study demonstrates that pretreatment with quinapril reduced the adverse effects of propofol on hemostasis, and co-administration of both drugs potentiated hypotension in rats, which corresponds to higher mortality. Expand
Propofol Suppresses Macrophage Functions and Modulates Mitochondrial Membrane Potential and Cellular Adenosine Triphosphate Synthesis
TLDR
A clinically relevant concentration of propofol can suppress macrophage functions, possibly through inhibiting their mitochondrial membrane potential and adenosine triphosphate synthesis instead of direct cellular toxicity. Expand
Platelet Function as Affected by Total Intravenous and Inhalational
TLDR
The results do not indicate any significant difference between propofol and sevoflurane as concerns blood loss and platelet inhibition. Expand
The effect of intraoperative colloid solutions coadministered with 6% hydroxyethyl starch (130/0.4) on platelet function in patients undergoing total intravenous anesthesia.
TLDR
Flood therapy with colloid solution that contained 6% HES (130/0.4) may diminish ADP-induced platelet aggregation intraoperatively in patients subjected to total intravenous anesthesia. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 28 REFERENCES
Propofol Inhibits In Vitro Platelet Aggregation in Human Whole Blood
TLDR
It is concluded that propofol reduces the platelet activity in human whole blood in vitro in a concentration-dependent and antiaggregant effect. Expand
In Vivo and In Vitro Studies of the Inhibitory Effect of Propofol on Human Platelet Aggregation
TLDR
Inhibition of platelet aggregation appeared to be caused by propofol itself and not by the fat emulsion, and was also supported by the suppressed influx and discharge of calcium. Expand
Platelet aggregation in human whole blood after chronic administration of aspirin.
TLDR
The impedance aggregometer was used to study the "ex vivo" effect of acetylsalicylic acid in whole blood (WB) versus platelet-rich plasma (PRP) in 35 male healthy volunteers and found that ASA shows a lower IC-50 in WB than in PRP. Expand
Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients
TLDR
A study was made on the inhibitory effect of triflusal and acetylsalicylic acid on platelet aggregation in whole blood and platelet‐rich plasma induced by ADP, in 30 insulin‐dependent diabetic patients without vascular complications. Expand
Effects of acetylsalicylic acid on platelet aggregation in male and female whole blood: an in vitro study.
TLDR
A higher ASA concentration was needed in order to produce half maximal inhibition of platelet aggregation in female than in male samples with both WB and PRP method, except when ADP was used as the aggregating agent in PRP. Expand
Effects of aspirin on platelet-neutrophil interactions. Role of nitric oxide and endothelin-1.
TLDR
The results show that a significant part of the effect of aspirin on platelet activation involves a neutrophil-mediated, NO/cGMP-dependent mechanism, and the presence of ET-1 counterbalances these effects of neutrophils on Platelet activation, therefore acting as an indirect proactivating agent. Expand
Dipyridamole inhibits platelet aggregation in whole blood.
TLDR
It is demonstrated that dipyridamole impedes platelet aggregation in whole blood by an interaction with red blood cells, probably involving adenosine. Expand
The in vitro effects of isoflurane, sevoflurane, and propofol on platelet aggregation
TLDR
It is demonstrated that sevoflurane and propofol had a significant inhibitory effect on intraoperative and early postoperative platelet aggregation, whereas isof lurane had no effect, and isofLurane may be preferred as a general anesthetic in patients with a clinically relevant bleeding tendency. Expand
Propofol does not affect platelet aggregation.
TLDR
The results show that propofol does not affect platelet aggregation in the concentrations used, and that platelet haemostasis is normal in patients undergoing anaesthesia and surgery. Expand
Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets
TLDR
It is likely that the inhibitory effect of NO on platelets represents the action of endogenous EDRF and therefore this substance, together with prostacyclin, is a regulator of platelet‐vessel wall interactions. Expand
...
1
2
3
...