Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

@article{Eikelboom2012AntiplateletDA,
  title={Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.},
  author={John W. Eikelboom and Jack Hirsh and Frederick A Spencer and Trevor P Baglin and Jeffrey I Weitz},
  journal={Chest},
  year={2012},
  volume={141 2 Suppl},
  pages={e89S-e119S}
}
The article describes the mechanisms of action, pharmacokinetics, and pharmacodynamics of aspirin, dipyridamole, cilostazol, the thienopyridines, and the glycoprotein IIb/IIIa antagonists. The relationships among dose, efficacy, and safety are discussed along with a mechanistic overview of results of randomized clinical trials. The article does not provide specific management recommendations but highlights important practical aspects of antiplatelet therapy, including optimal dosing, the… CONTINUE READING
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