Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice.

@article{Sun2007AntiplateletAE,
  title={Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice.},
  author={D-S Sun and C-C King and H-S Huang and Y-L Shih and Chien-Chang Lee and W-J Tsai and C. L. Yu and H Chang},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2007},
  volume={5 11},
  pages={2291-9}
}
BACKGROUND The mechanisms responsible for thrombocytopenia associated with dengue fever (DF) and dengue hemorrhage fever (DHF) remain unclear. OBJECTIVE In this study, we investigated the pathogenic effects of dengue virus (DENV) non-structural protein 1 (NS1) on the elicitation of platelet cross-reactive antibodies. RESULTS The results showed that anti-DENV NS1 immunoglobulins (Igs) derived from both patients with DF/DHF and recombinant NS1-immunized rabbits could opsonize normal human… CONTINUE READING