Antiplatelet agents for preventing pre-eclampsia and its complications.

@article{Duley2004AntiplateletAF,
  title={Antiplatelet agents for preventing pre-eclampsia and its complications.},
  author={Lelia Duley and David J Henderson-smart and Marian Knight and J. Fergus King},
  journal={The Cochrane database of systematic reviews},
  year={2004},
  volume={1},
  pages={
          CD004659
        }
}
BACKGROUND Pre-eclampsia is associated with deficient intravascular production of prostacyclin, a vasodilator, and excessive production of thromboxane, a platelet-derived vasoconstrictor and stimulant of platelet aggregation. These observations led to the hypotheses that antiplatelet agents, low-dose aspirin in particular, might prevent or delay the development of pre-eclampsia. OBJECTIVES To assess the effectiveness and safety of antiplatelet agents when given to women at risk of developing… 

Antiplatelet agents for preventing pre-eclampsia and its complications.

TLDR
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WHO recommendation on timing of low-dose acetylsalicylic acid (aspirin) for pre-eclampsia prevention in high-risk women

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  • 2019
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The guideline development group acknowledged that in settings where 75 mg aspirin tablets are not available, the available dose nearest to 75 mg should be used, and there is a paucity of evidence to suggest that any subset of women within the high-risk group would benefit from aspirin therapy.

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The aim of this study was to find ways to predict pre-eclampsia and test the performance of low dose aspirin in the prevention of pre- eClampsia in women at high risk and to assess the role of vasoactive agents in the prediction.

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...

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TLDR
Antiplatelet agents, in this review largely low dose aspirin, have small-moderate benefits when used for prevention of pre-eclampsia.

Antiplatelet drugs for prevention of pre-eclampsia and its consequences: systematic review

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Antiplatelet drugs, largely low dose aspirin, have small to moderate benefits when used for prevention of pre-eclampsia and its consequences.

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TLDR
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In 7 patients with manifest pre-eclampsia or pregnancy-induced hypertension the circulating eicosanoid concentrations were determined before and during Trapidil medication, and trapidil was associated with an about twofold increase of 6-keto PGF1 alpha concentration in the peripheral venous blood, while the concentration of thromboxane A2 revealed no changes.

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TLDR
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...