Antiplasmodial structure-activity relationship of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives.

@article{Marn2008AntiplasmodialSR,
  title={Antiplasmodial structure-activity relationship of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives.},
  author={A. Mar{\'i}n and L{\'i}dia Moreira Lima and B. Solano and E. Vicente and Silvia P{\'e}rez Silanes and S. Maurel and M. Sauvain and I. Aldana and A. Monge and E. Deharo},
  journal={Experimental parasitology},
  year={2008},
  volume={118 1},
  pages={
          25-31
        }
}
Derivatives of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide (4b-g, 5b-g, 6a-g) were synthesized and evaluated for their capacity to inhibit the growth of chloroquine-resistant Plasmodium falciparum FCB1 strain in culture. Compound 7-chloro-2-(2-furylcarbonyl)-3-trifluoromethyl-1,4-quinoxaline di-N-oxide (5g) was the most active being almost 5 times more active than chloroquine. It was also 50 times more active against P. falciparum than toxic toward MCF7 cells. Structural… Expand
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