Antiplasmodial flavonoids from Erythrina sacleuxii.

  title={Antiplasmodial flavonoids from Erythrina sacleuxii.},
  author={A. Andayi and A. Yenesew and S. Derese and J. Midiwo and P. Gitu and O. J. Jondiko and H. Akala and P. Liyala and Julia M. Wangui and N. Waters and M. Heydenreich and M. Peter},
  journal={Planta medica},
  volume={72 2},
The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4'-methoxy-3'-prenylisoflavone (trivial name 5-deoxy-3'-prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from… Expand
Antiplasmodial prenylated flavonoids from stem bark of Erythrina latissima
Abstract The antiplasmodial activity against Plasmodium falciparum strain K1 as well as cytotoxicity against MRC-5 cells of 15 prenylated flavonoids obtained from Erythrina latissima E. MeyExpand
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From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized and showed moderate to good antiplasmodial activity. Expand
Chemical constituents of the root wood of Erythrina sacleuxii and determination of the absolute configuration of suberectin
Phytochemical investigation on the root wood of Erythrina sacleuxii (Leguminosae) led to the isolation of nine secondary metabolites (1-9). Compound 1 was isolated from the genus Erythrina for theExpand
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The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against the chloroquine-sensitive and chloroquin-resistant strains of Plasmodium falciparum with IC(50) values of 0.97 ± 0.2 and 1.5 μg/ml respectively, and in vivo antimalarial activity with 52% chemosuppression. Expand
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Abstract From the seedpods of Tephrosia elata , a new β-hydroxydihydrochalcone named ( S )-elatadihydrochalcone was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatinExpand
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The phytochemical screening of ethanol extract of the dried bark of Erythrina fusca Lour, determined the presence of alkaloids, flavonoids, terpenes, and quinones, which presented a moderate antiplasmodial activity in NF54 and FCB-2 strains of Plasmodium falciparum. Expand
Antibacterial activity of flavonoids from the stem bark of Erythrina caffra thunb.
This is the first report of antibacterial activity of burttinone and the isolation of these compounds from E. caffra is reported, active against both Gram‐negative and Gram‐positive bacteria. Expand
Prenylated isoflavones from the stem bark of Erythrina sacleuxii
Abstract Two new prenylated isoflavones, named erysacleuxin A (1) and B (2), along with eight known compounds, biochanin A (3), 5′-(3-methylbut-2-enyl)pratensein (4), 7-demethylrobustigenin (5),Expand
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The MeOH extract and compounds 2–5 were non-toxic to human red blood cells indicating their high selectivity to be used as antimicrobial and antioxidant drugs. Expand
4′-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species
Abstract The CH 2 Cl 2 /MeOH (1:1) extract of the stem bark of Millettia oblata ssp. teitensis showed antiplasmodial activity (IC 50  = 10–12 μg/mL) against the chloroquine-sensitive (D6) andExpand