Antiplasmodial and antioxidant isoquinoline alkaloids from Dehaasia longipedicellata.

  title={Antiplasmodial and antioxidant isoquinoline alkaloids from Dehaasia longipedicellata.},
  author={Azeana Zahari and Foo Kit Cheah and Jamaludin Mohamad and Syazreen Nadia Sulaiman and Marc Litaudon and Kok Hoong Leong and Khalijah Awang},
  journal={Planta medica},
  volume={80 7},
The crude extract of the bark of Dehaasia longipedicellata exhibited antiplasmodial activity against the growth of Plasmodium falciparum K1 isolate (resistant strain). Phytochemical studies of the extract led to the isolation of six alkaloids: two morphinandienones, (+)-sebiferine (1) and (-)-milonine (2); two aporphines, (-)-boldine (3) and (-)-norboldine (4); one benzlyisoquinoline, (-)-reticuline (5); and one bisbenzylisoquinoline, (-)-O-O-dimethylgrisabine (6). Their structures were… 
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