Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives

@article{Zarranz2006AntiplasmodialAO,
  title={Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives},
  author={B. Zarranz and A. Jaso and L. M. Lima and I. Aldana and A. Monge and S. Maurel and M. Sauvain},
  journal={Revista Brasileira De Ciencias Farmaceuticas},
  year={2006},
  volume={42},
  pages={357-361}
}
The in vitro antiplasmodial activity of some 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain (chloroquine-resistant) of P. falciparum and the most interesting compounds were then evaluated on MCF7 tumor cells in order to evaluate an index of selectivity. The 7-methyl (2b, 4b, 5b, 6b) and nonsubstituted (3c, 4c, 5c) quinoxaline 1,4-dioxide derivatives presented the best level of activity. 

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