Antiplasmodial Activities of Homogentisic Acid Derivative Protein Kinase Inhibitors Isolated from a Vanuatu Marine Sponge Pseudoceratina sp.

@article{Lebouvier2009AntiplasmodialAO,
  title={Antiplasmodial Activities of Homogentisic Acid Derivative Protein Kinase Inhibitors Isolated from a Vanuatu Marine Sponge Pseudoceratina sp.},
  author={N. Lebouvier and V. Jullian and I. Desvignes and S. Maurel and A. Parenty and Dominique Dorin-semblat and C. Doerig and M. Sauvain and D. Laurent},
  journal={Marine Drugs},
  year={2009},
  volume={7},
  pages={640 - 653}
}
As part of our search for new antimalarial drugs in South Pacific marine sponges, we have looked for inhibitors of Pfnek-1, a specific protein kinase of Plasmodium falciparum. On the basis of promising activity in a preliminary screening, the ethanolic crude extract of a new species of Pseudoceratina collected in Vanuatu was selected for further investigation. A bioassay-guided fractionation led to the isolation of a derivative of homogentisic acid [methyl (2,4-dibromo-3,6-dihydroxyphenyl… Expand
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