Antiphospholipid syndrome

  title={Antiphospholipid syndrome},
  author={Guillermo Ruiz-Irastorza and Mark Andrew Crowther and Ware D Branch and Munther A. Khamashta},
  journal={The Lancet},
The antiphospholipid syndrome causes venous, arterial, and small-vessel thrombosis; pregnancy loss; and preterm delivery for patients with severe pre-eclampsia or placental insufficiency. Other clinical manifestations are cardiac valvular disease, renal thrombotic microangiopathy, thrombocytopenia, haemolytic anaemia, and cognitive impairment. Antiphospholipid antibodies promote activation of endothelial cells, monocytes, and platelets; and overproduction of tissue factor and thromboxane A2… Expand
Immunotherapy in antiphospholipid syndrome.
New potential therapeutic approaches have been proposed, including the use of new oral anticoagulants, statins, hydroxychloroquine, coenzyme Q10, B-cell depletion, platelet and TF inhibitors, peptide therapy or complement inhibition among others. Expand
Managing antiphospholipid syndrome in pregnancy.
Careful, well monitored obstetric care with the use of aspirin and heparin has likely improved the pregnancy outcome in obstetric APS and currently approximately 70-80% of pregnant women with APS have a successful pregnancy outcome, however, the current standard of care does not prevent all pregnancy complications as the current treatment fails in 20-30% of APS pregnancies. Expand
The antiphospholipid syndrome: from pathophysiology to treatment
The objective of this review paper is to summarize the recent literature on APS from pathogenesis to current therapeutic options. Expand
Potential Use of Statins in the Treatment of Antiphospholipid Syndrome
In APS, statins have multiple profound effects on monocyte, lymphocyte, and endothelial cell activities, all of which may contribute to thrombosis prevention in APS patients, Nevertheless, larger randomized trials are needed to validate the role of statins in the treatment of this autoimmune disease. Expand
Tomography and blood vessels in Hughes syndrome
Computed tomographic angiography (CTA) seems to be the most precise method with low exposure time, giving clinicians an opportunity for early diagnosis and timely treatment of APS patients. Expand
Antiphospholipid syndrome: Diagnosis and management in the obstetric patient.
  • E. Arslan, D. Branch
  • Medicine
  • Best practice & research. Clinical obstetrics & gynaecology
  • 2019
In this chapter, diagnostic, clinical, and therapeutic approaches in the treatment of APS syndrome in pregnancy are discussed. Expand
Current treatment of antiphospholipid syndrome: lights and shadows
This Review focuses on the current recommendations for thrombotic and obstetric manifestations of APS, as well as the management of difficult cases. Expand
Obstetric antiphospholipid syndrome and long term arterial thrombosis risk
The data suggests that women with obstetric APS are at risk for subsequent long-term thrombosis, especially arterial cerebral events, and did not identify any clinical or laboratory unique features among women with maternity APS who will eventually develop thromBosis. Expand
The management of obstetric antiphospholipid syndrome
All pregnant women with APS should be considered to be at high risk and be managed in combined medical-obstetrical clinic throughout the whole pregnancy to increase the chances for delivery of live and healthy baby. Expand
[Pregnancy and antiphospholipid syndrome].
Treatment optimization and multidisciplinary antenatal care improve the prognosis of pregnancies in women with obstetric APS, leading to a favorable outcome most of the time. Expand