Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants.

  title={Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants.},
  author={J M M C Arnout},
  journal={Thrombosis and haemostasis},
  volume={86 1},
Antiphospholipid syndrome (APS) is an autoimmune disorder in which antiphospholipid antibodies (aPL) are thought to be involved in the development of venous and/or arterial thrombosis. APL found in this syndrome are antibodies directed against a variety of phospholipid (PL) binding-proteins of which beta3-glycoprotein I (beta2GPI) and prothrombin are considered to be the major antigens. Some of these antibodies prolong PL-dependent clotting reactions and are termed lupus anticoagulants (LA… CONTINUE READING


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