Antiphospholipid syndrome: an overview.

  title={Antiphospholipid syndrome: an overview.},
  author={John G. Hanly},
  journal={CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne},
  volume={168 13},
  • John G. Hanly
  • Published 2003 in
    CMAJ : Canadian Medical Association journal…
Antiphospholipid antibodies are a heterogeneous group of autoantibodies that are detected by immunoassays and functional coagulation tests. The antigenic targets are negatively charged phospholipids and serum phospholipid-binding proteins. The latter antibodies are frequently associated with thrombosis, fetal loss and other clinical manifestations of the antiphospholipid syndrome. These antibodies are felt to be etiologically important in the syndrome, although the precise pathogenic mechanisms… CONTINUE READING
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