Antiphospholipid immunoglobulin G antibodies reduce annexin-V levels on syncytiotrophoblast apical membranes and in culture media of placental villi.

@article{Rand1997AntiphospholipidIG,
  title={Antiphospholipid immunoglobulin G antibodies reduce annexin-V levels on syncytiotrophoblast apical membranes and in culture media of placental villi.},
  author={Jacob H. Rand and X X Wu and S. A. Guller and Jordan M. Scher and Hannelore Andree and Charles Joseph Lockwood},
  journal={American journal of obstetrics and gynecology},
  year={1997},
  volume={177 4},
  pages={918-23}
}
OBJECTIVES The mechanism by which antiphospholipid antibodies are associated with pregnancy loss and thromboembolism has not been established. We previously showed that annexin-V, a phospholipid-binding protein with potent anticoagulant activity, is present on the apical membranes of the syncytiotrophoblasts that line placental villi and that this protein is reduced, by immunohistochemistry, on placentas of patients with antiphospholipid antibodies. We therefore investigated whether annexin-V… CONTINUE READING