Antiphospholipid antibody syndrome: the flow cytometric annexin A5 competition assay as a diagnostic tool.

@article{Tomer2007AntiphospholipidAS,
  title={Antiphospholipid antibody syndrome: the flow cytometric annexin A5 competition assay as a diagnostic tool.},
  author={Aaron Tomer and Shaul K. Bar-Lev and Seth Fleisher and Boris Shenkman and Michael Friger and Mahmoud Abu-Shakra},
  journal={British journal of haematology},
  year={2007},
  volume={139 1},
  pages={113-20}
}
The mechanism underlying hypercoagulability in antiphospholipid antibody syndrome (APS) is uncertain. Here, we present a flow-cytometric assay (FCA) based on the hypothesis that anti-platelet-anionic-phospholipid autoantibodies (aPL) interfere with the activity of the natural anticoagulant protein annexin A5, thereby accelerating platelet procoagulant activity. This study assessed the clinical utility of the feasible FCA, which demonstrates the competition of the patient's aPL with the binding… CONTINUE READING