Antiphospholipid antibodies promote tissue factor-dependent angiogenic switch and tumor progression.

@article{Wu2014AntiphospholipidAP,
  title={Antiphospholipid antibodies promote tissue factor-dependent angiogenic switch and tumor progression.},
  author={Yuan-Yuan Wu and Andrew V Nguyen and X Wu and Mingyu Loh and Michelle Vu and Y. M. Zou and Qiang Liu and Peng Guo and Yanhua Wang and Leslie L. Montgomery and Amos Z. Orlofsky and Jacob H. Rand and E. Y.-T. Lin},
  journal={The American journal of pathology},
  year={2014},
  volume={184 12},
  pages={3359-75}
}
Progression to an angiogenic state is a critical event in tumor development, yet few patient characteristics have been identified that can be mechanistically linked to this transition. Antiphospholipid autoantibodies (aPLs) are prevalent in many human cancers and can elicit proangiogenic expression in several cell types, but their role in tumor biology is unknown. Herein, we observed that the elevation of circulating aPLs among breast cancer patients is specifically associated with invasive… CONTINUE READING