Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H.

@article{Horstmann1988AntiphagocyticAO,
  title={Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H.},
  author={R Horstmann and H J Sievertsen and Juergen Knobloch and Vincent A. Fischetti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 5},
  pages={1657-61}
}
Isolated complement components were used to study the regulation of the alternative complement pathway C3 convertase (EC 3.4.21.47), also called C3b,Bb, on M protein-carrying (M+) and M protein-lacking (M-) streptococci. Neither M- nor M+ streptococci directly affected the formation or dissociation of the surface-bound C3b,Bb or the inactivation of surface-bound C3b by factor I. However, the activity of the serum control protein of the alternative complement pathway, factor H, in controlling… CONTINUE READING

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