Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease.

@article{Greenamyre1994AntiparkinsonianEO,
  title={Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease.},
  author={J Timothy Greenamyre and R V Eller and Zhen-wei Zhang and Aliza Ovadia and Roger M. Kurlan and Don Marshall Gash},
  journal={Annals of neurology},
  year={1994},
  volume={35 6},
  pages={655-61}
}
Loss of dopaminergic innervation of the striatum results in overactivity of the glutamatergic pathways from the subthalamic nucleus to the internal segment of the globus pallidus and the substantia nigra pars reticulata, the output nuclei of the basal ganglia. Previous work has shown that local blockade of glutamate receptors in the internal segment of the globus pallidus or substantia nigra pars reticulata leads to marked suppression of parkinsonian signs. We have now examined whether systemic… CONTINUE READING
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