Antiparkinsonian dopamine agonists: a review of the pharmacokinetics and neuropharmacology in animals and humans.

@article{Wachtel1991AntiparkinsonianDA,
  title={Antiparkinsonian dopamine agonists: a review of the pharmacokinetics and neuropharmacology in animals and humans.},
  author={Helmut Wachtel},
  journal={Journal of neural transmission. Parkinson's disease and dementia section},
  year={1991},
  volume={3 3},
  pages={151-201}
}
  • Helmut Wachtel
  • Published 1991 in
    Journal of neural transmission. Parkinson's…
With the intention of compensating for the deficit of endogenous dopamine (DA) in the basal ganglia of Parkinsonian patients by substitution with agents which directly stimulate central DA receptors, synthetic DA agonists have been introduced almost 20 years ago for the symptomatic treatment of Parkinson's disease. The original expectation that DA agonists would be able to completely restore extrapyramidal motor function in Parkinsonian patients has turned out as too mechanistic and… CONTINUE READING

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