Corpus ID: 26390600

Antiparkinsonian Effects of BAM‐1110, a Novel Ergoline Derivative, in MPTP‐Treated Cynomolgus Monkeys

@article{Kuno1998AntiparkinsonianEO,
  title={Antiparkinsonian Effects of BAM‐1110, a Novel Ergoline Derivative, in MPTP‐Treated Cynomolgus Monkeys},
  author={S. Kuno and E. Mizuta and H. Sakamoto and K. Ichihara and M. Nagasaka},
  journal={Clinical Neuropharmacology},
  year={1998},
  volume={21},
  pages={35–40}
}
BAM-1110 [(5R,8R,10R)-6-methyl–8–(1,2,4-triazol-l-ylmethyl) ergoline maleate] is a newly synthesized dopamine agonist that produces little anorexic side effects (nausea and vomiting). The current study examines the effects of BAM-1110 on parkinsonian symptoms in l-methyl–4–phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, an animal model of Parkinson's disease. First, a significant antiparkinsonian effect of apomorphine hydrochloride (0.3 mg/kg given subcutaneously) was confirmed in… Expand
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