Antiparasitic nitroimidazoles. IV. Serum protein binding and mode of action of 2-(4'-carboxystyryl)-5-nitro-1-vinylimidazole.

@article{Tarrant1973AntiparasiticNI,
  title={Antiparasitic nitroimidazoles. IV. Serum protein binding and mode of action of 2-(4'-carboxystyryl)-5-nitro-1-vinylimidazole.},
  author={Malcolm E. Tarrant and S Wedley and Trevor J. Woodage and John N. Green},
  journal={Biochemical pharmacology},
  year={1973},
  volume={22 5},
  pages={
          639-49
        }
}
Abstract The serum protein binding, uptake by parasites and mode of action of 2-(4'-carboxystyryl)-5-nitro-1-vinylimidazole (I) were investigated. Compound I was strongly bound to serum proteins in all species, especially the rat. The albumin of this species appeared to possess a single high-affinity site not present in mouse or dog albumin. Only unbound I was taken up by Trichomonas vaginalis . In vitro , a short exposure of Trichomonas vaginalis to levels of I above 5 μg/ml led to their… CONTINUE READING

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