Antiparasitic alkaloids from Psychotria klugii.

  title={Antiparasitic alkaloids from Psychotria klugii.},
  author={Ilias Muhammad and Daniel Dunbar and Shabana Iqrar Khan and Babu L. Tekwani and Erdal Bedir and Satoshi Takamatsu and Daneel Ferreira and Larry A Walker},
  journal={Journal of natural products},
  volume={66 7},
Psychotria klugii yielded two new benzoquinolizidine alkaloids, klugine (1) and 7'-O-demethylisocephaeline (2), together with the previously known cephaeline (3), isocephaeline (4), and 7-O-methylipecoside (5). The structures and stereochemistry of 1 and 2 were determined by 1D and 2D NMR data and circular dichroism experiments. Cephaeline (3) demonstrated potent in vitro antileishmanial activity against Leishmania donavani (IC(50) 0.03 microg/mL) and was >20- and >5-fold more potent than… CONTINUE READING
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