Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide.

@article{Cerf2009AntiparallelBA,
  title={Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide.},
  author={Emilie Cerf and Rabia Sarroukh and Shiori Tamamizu-Kato and Leonid Breydo and Sylvie Derclaye and Yves F Dufr{\^e}ne and Vasanthy Narayanaswami and Erik Goormaghtigh and J. -M. Ruysschaert and Vincent Raussens},
  journal={The Biochemical journal},
  year={2009},
  volume={421 3},
  pages={415-23}
}
AD (Alzheimer's disease) is linked to Abeta (amyloid beta-peptide) misfolding. Studies demonstrate that the level of soluble Abeta oligomeric forms correlates better with the progression of the disease than the level of fibrillar forms. Conformation-dependent antibodies have been developed to detect either Abeta oligomers or fibrils, suggesting that structural differences between these forms of Abeta exist. Using conditions which yield well-defined Abeta-(1-42) oligomers or fibrils, we studied… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Similar Papers

Loading similar papers…