Antioxidative treatment prevents activation of death-receptor- and mitochondrion-dependent apoptosis in the hearts of diabetic rats

@article{Bojunga2004AntioxidativeTP,
  title={Antioxidative treatment prevents activation of death-receptor- and mitochondrion-dependent apoptosis in the hearts of diabetic rats},
  author={Joerg Bojunga and Dorota Nowak and P. S. Mitrou and Dieter Hoelzer and Stefan Zeuzem and Kai Uwe Chow},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={2072-2080}
}
The mechanisms by which glucose injures cells of the cardiovascular system include generation of reactive oxygen species and induction of cellular apoptosis. To date, little is known about the molecular events of hyperglycaemia-induced apoptosis in the heart in vivo. Male Sprague–Dawley rats were rendered diabetic by a single intraperitoneal injection of 60 mg/kg body weight streptozotocin. Caspase activities in cardiac ventricular tissue were determined using fluorometric and immunoassay… CONTINUE READING
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