Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells.

@article{Szotowski2007AntioxidativeTI,
  title={Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells.},
  author={Bjoern Szotowski and Silvio Antoniak and Petra Goldin-Lang and Quoc-Viet Tran and Klaus Pels and Peter Rosenthal and Vladimir Y. Bogdanov and H. -H. Borchert and Heinz-Peter Schultheiss and Ursula Rauch},
  journal={Cardiovascular research},
  year={2007},
  volume={73 4},
  pages={806-12}
}
OBJECTIVES The aim of this study was to investigate the effect of the antioxidants pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC) on the ionizing radiation (IR)- and tumor necrosis factor-alpha (TNF-alpha) induced tissue factor (TF) expression and its release from human umbilical vein endothelial cells (HUVECs). METHODS HUVECs were irradiated with a single dose of either 5 Gy or 10 Gy and stimulated with TNF-alpha (10 ng/mL) in the presence or absence of PDTC and NAC… CONTINUE READING