Antioxidative therapy in an ex vivo human cartilage trauma-model: attenuation of trauma-induced cell loss and ECM-destructive enzymes by N-acetyl cysteine.

@article{Riegger2016AntioxidativeTI,
  title={Antioxidative therapy in an ex vivo human cartilage trauma-model: attenuation of trauma-induced cell loss and ECM-destructive enzymes by N-acetyl cysteine.},
  author={Jana Riegger and Helga Joos and H G Palm and Benedikt Friemert and Heiko Reichel and Anita Ignatius and Rolf E Brenner},
  journal={Osteoarthritis and cartilage},
  year={2016},
  volume={24 12},
  pages={2171-2180}
}
OBJECTIVE Mechanical trauma of articular cartilage results in cell loss and cytokine-driven inflammatory response. Subsequent accumulation of reactive oxygen (ROS) and nitrogen (RNS) species enhances the enzymatic degradation of the extracellular matrix (ECM). This study aims on the therapeutic potential of N-acetyl cysteine (NAC) in a human ex vivo cartilage trauma-model, focusing on cell- and chondroprotective features. DESIGN Human full-thickness cartilage explants were subjected to a… CONTINUE READING