Antioxidative role of melatonin in organophosphate toxicity in rats

  title={Antioxidative role of melatonin in organophosphate toxicity in rats},
  author={Mehmet Emin Buyukokuroglu and Mustafa Cemek and Yusuf Yurumez and Y{\"u}cel Yavuz and Adem Aslan},
  journal={Cell Biology and Toxicology},
Previous studies revealed that oxidative stress could be an important component of the mechanism of organophosphate (OP) compound toxicity. The aim of the present study was to investigate both prophylactic and therapeutic effects of melatonin against fenthion-induced oxidative stress in rats. Therefore, we determined the changes in the levels of reduced glutathione (GSH) and malondialdehyde (MDA) in the whole blood, brain, pectoral muscle, liver, lung, heart, kidney, pancreas, and jejunum. Also… CONTINUE READING
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