Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice.

@article{Wang2006AntioxidativeFA,
  title={Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice.},
  author={Jiangxue Wang and Chunying Chen and Bai Li and Hongwei Yu and Yuliang Zhao and Jin Sun and Yufeng Li and Gengmei Xing and Hui Yuan and Jun Tang and Zhen Chen and Huan Meng and Yuxi Gao and Chang Gen Ye and Zhifang Chai and Chuanfeng Zhu and Baocheng Ma and Xiaohong Fang and Lijun Wan},
  journal={Biochemical pharmacology},
  year={2006},
  volume={71 6},
  pages={872-81}
}
Oxidative stress is considered to be one of the important mechanisms involved in carcinogenesis. In our previous study, gadolinium endohedral metallofullerenol ([Gd@C82(OH)22]n nanoparticles) have shown high inhibitory activity on hepatoma cell (H22) growth in mice. To explore the antioxidative functions of nanoparticles, we investigated the biodistribution of [Gd@C82(OH)22]n nanoparticles, the changes of blood coagulation profiles, the metabolism of reactive oxygen species (ROS) in the tumor… CONTINUE READING
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