Antioxidative effects of melatonin in Drosophila melanogaster: antagonization of damage induced by the inhibition of catalase.

@article{CotoMontes1999AntioxidativeEO,
  title={Antioxidative effects of melatonin in Drosophila melanogaster: antagonization of damage induced by the inhibition of catalase.},
  author={Ana Coto-Montes and R{\"u}diger Hardeland},
  journal={Journal of pineal research},
  year={1999},
  volume={27 3},
  pages={154-8}
}
In Drosophila melanogaster strain Canton S, the catalase inhibitor 3-amino-1,2,4-triazole was used to enhance oxidative stress from endogenous sources. This treatment was chosen as an alternative to direct administration of oxidants, which would cause damage and interact with melatonin already in the extracellular space before they reach the intracellular compartments. Male flies were kept in constant darkness and fed 1% sucrose as the only diet, with or without additions of melatonin (2 mM… CONTINUE READING

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