• DOI:10.1021/JF021159T
• Corpus ID: 10444905

Antioxidative and hepatoprotective effects of Antrodia camphorata extract.

@article{Hsiao2003AntioxidativeAH,
  title={Antioxidative and hepatoprotective effects of Antrodia camphorata extract.},
  author={George Hsiao and Ming-Yi Shen and Kuan Hung Lin and Ming-Huang Lan and Li-Yu Wu and Duen-Suey Chou and Chien-Huang Lin and Ching Hua Su and Joen-Rong Sheu},
  journal={Journal of agricultural and food chemistry},
  year={2003},
  volume={51 11},
  pages={
          3302-8
        }
}

• G. Hsiao, M. Shen, +6 authors J. Sheu
• Published 29 April 2003
• Biology, Chemistry, Medicine
• Journal of agricultural and food chemistry

Antrodia camphorata (A. camphorata) is well-known in Taiwan as a traditional Chinese medicine. The purpose of this study was to evaluate the ability of A. camphorata extracts to protect against oxidative stress in vitro and against carbon tetrachloride (CCl(4))-induced hepatic injury in vivo. An extract of A. camphorata inhibited nonenzymatic iron-induced lipid peroxidation in rat brain homogenates with an IC(50) value about 3.1 mg/mL. It also scavenged the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). The dose of the A. camphorata extract resulting in a decrease of 0.20 in the absorbance of DPPH was about 31 +/- 0.7 microg/mL. Furthermore, an A. camphorata extract dose-dependently (250-1250 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated CCl(4) intoxication in mice. Moreover, A. camphorata extract significantly improved the CCl(4)-induced increase in hepatic glutathione peroxidase, reductase, and CCl(4)-induced decrease in superoxide dismutase activities. It also restored the decrement in the glutathione content and catalase activity of hepatic tissues in CCl(4)-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during CCl(4) treatment. Histopathological changes of hepatic lesions induced by CCl(4) were significantly ameliorated by treatment with an A. camphorata extract in a dose-dependent manner. These results suggest that A. camphorata extract exerts effective protection against chronic chemical-induced hepatic injury in vivo, by mediating antioxidative and free radical scavenging activities.