Antioxidants reversibly inhibit the spontaneous resumption of meiosis.

  title={Antioxidants reversibly inhibit the spontaneous resumption of meiosis.},
  author={Masao Takami and Sean L Preston and V A Toyloy and Harold R Behrman},
  journal={The American journal of physiology},
  volume={276 4 Pt 1},
We previously showed that the cell-permeant antioxidant 2(3)- tert-butyl-4-hydroxyanisole (BHA) inhibited germinal vesicle breakdown (GVBD) in oocyte-cumulus complexes (OCC) of the rat. The objective of the present studies was to assess other antioxidants and whether such inhibition was reversible. Spontaneous GVBD in OCC incubated for 2 h was significantly inhibited ( P < 0.005) by nordihydroguaiaretic acid (NDGA; GVBD = 19.4%), BHA (GVBD = 25.7%), octyl gallate (OG; GVBD = 52.2%), ethoxyquin… CONTINUE READING