Antioxidants reverse the changes in energy metabolism of rat brain after chronic administration of L.-tyrosine

@article{Teodorak2016AntioxidantsRT,
  title={Antioxidants reverse the changes in energy metabolism of rat brain after chronic administration of L.-tyrosine},
  author={Brena Pereira Teodorak and Giselli Scaini and Milena Carvalho-Silva and Lara Mezari Gomes and Let{\'i}cia J. Teixeira and Joyce Rebelo and Samira Dal To{\'e} De Pr{\'a} and N. Zeni and Patricia F Schuck and Gustavo C Ferreira and Emilio Luiz Streck},
  journal={Metabolic Brain Disease},
  year={2016},
  volume={32},
  pages={557-564}
}
Tyrosinemia type II is a rare autosomal recessive disease caused by deficiency of hepatic tyrosine aminotransferase and is associated with neurologic and development difficulties in numerous patients. Considering that the mechanisms underlying the neurological dysfunction in hypertyrosinemic patients are poorly known and that high concentrations of tyrosine provoke mitochondrial dysfunction and oxidative stress, in the present study we investigated the in vivo influence of antioxidants (N… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 79 REFERENCES

Disorders of tyrosine catabolism.

  • Molecular genetics and metabolism
  • 2006
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Tyrosinemia: A Review

  • Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2001
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

The characterization of neuroenergetic effects of chronic L-tyrosine administration in young rats: evidence for striatal susceptibility

GK Ferreira
  • Metab Brain Dis 30:215–221
  • 2015

An evaluation of the effects of acute and chronic L-tyrosine administration on BDNF levels and BDNF mRNA expression in the rat brain

GK Ferreira
  • Mol Neurobiol 49:734–740
  • 2014

Nacetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities. Brain and behavior 4:108–122

R Bavarsad Shahripour, MR Harrigan, AV Alexandrov
  • 2014
VIEW 2 EXCERPTS