Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice.

@article{GarciaAlloza2010AntioxidantsHA,
  title={Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice.},
  author={Monica Garcia-Alloza and Laura Ann Borrelli and Bradley T. Hyman and Brian J. Bacskai},
  journal={Neurobiology of aging},
  year={2010},
  volume={31 12},
  pages={2058-68}
}
Senile plaques are a major pathological hallmark of Alzheimer's disease (AD). Compelling evidence suggests that senile plaques lead to structural alterations of neuronal processes and that local toxicity may be mediated by increased oxidative stress. Anti-oxidant therapy can alleviate the neuronal abnormalities in APP mice, but the time-course of this beneficial effect is unknown. We used multiphoton microscopy to assess in vivo the characteristics of antioxidant treatment on senile plaques and… CONTINUE READING
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