Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat.

@article{Andziak2005AntioxidantsDN,
  title={Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat.},
  author={Blazej Andziak and Timothy P O'Connor and Rochelle Buffenstein},
  journal={Mechanisms of ageing and development},
  year={2005},
  volume={126 11},
  pages={1206-12}
}
The maximum lifespan of naked mole-rats (NMRs; Heterocephalus glaber) is greater than that of any other rodent. These hystricognaths survive in captivity >28 years, eight-times longer than similar-sized mice. The present study tested if NMRs possess superior antioxidant defenses compared to mice and if age-related interspecies changes in antioxidants were evident. Activities of Cu/Zn superoxide dismutase (Cu/Zn, SOD), Mn SOD, catalase and cellular glutathione peroxidase (cGPx) were measured in… CONTINUE READING