Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins

  title={Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins},
  author={Vadim Z. Lankin and Alla K. Tikhaze and Valery V. Kukharchuk and Galina G. Konovalova and Oleg Pisarenko and Alexander I. Kaminnyi and Konstantin B Shumaev and Yu. N. Belenkov},
  journal={Molecular and Cellular Biochemistry},
The oxidative modification of low density lipoprotein (LDL) is thought to play an important role in atherogenesis. Drugs of β-hydroxy-β-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) family are usually used as a very effective lipid-lowering preparations but they simultaneously block biosynthesis of both cholesterol and ubiquinone Q10 (coenzyme Q), which is an intermediate electron carrier in the mitochondrial respiratory chain. It is known that reduced form of ubiquinone… 
Statins and Modulation of Oxidative Stress
  • J. Bełtowski
  • Biology, Chemistry
    Toxicology mechanisms and methods
  • 2005
The antioxidant effect of statins contributes to inhibition of atherogenesis, stabilization of atherosclerotic plaque, inhibition of myocardial hypertrophy and remodeling, and modulation of vascular tone.
The initiation of free radical peroxidation of low-density lipoproteins by glucose and its metabolite methylglyoxal: a common molecular mechanism of vascular wall injure in atherosclerosis and diabetes
The administration of sugar-lowering drug metformin caused a stronger inhibition of LDL peroxidation in the blood of patients with diabetes mellitus, probably due to decrease in methylglyoxal-dependent generation of superoxide anion-radicals.
Statin-Induced Liver Injury Involves Cross-Talk between Cholesterol and Selenoprotein Biosynthetic Pathways
It is concluded that statins inhibit the expression of inducible selenoproteins by preventing the mevalonate-dependent maturation of the single human selenocysteine-tRNA and may thereby evoke an increased vulnerability of the liver to secondary toxins.
The Issues of Antioxidant Therapy
Antioxidants are generally considered to have the capability to protect people from harmful effects of reactive oxygen and nitrogen species (RONSs), including free radicals, when these are present in excessive amounts.
Cardiovascular effects of resveratrol and atorvastatin treatments in an H2O2-induced stress model
Pretreatment with R+A for CVD appears to be superior to pretreatment with either agent alone, and this effect was mediated via the vascular endothelium.
Anti-Atherogenic Activity of Ethanolic Fraction of Terminalia arjuna Bark on Hypercholesterolemic Rabbits
Results show that T. arjuna extract can effectively prevent the progress of atherosclerosis and is likely due to the effect of T.Arjuna on serum lipoproteins and its antioxidant and anti-inflammatory properties.
Comparing the Effects of Lovastatin and Cornus Mas Fruit on Fibrinogen Level in Hypercholesterolemic Rabbits
Consumption of cornus mas L. powder might be beneficial in atherosclerotic patients due to its reducing effects on fibrinogen, as indicated by the results of this study.
Anti-oxidant and anti-hyperlipidemic activity of Hemidesmus indicus in rats fed with high-fat diet
Oral administration of methanolic extract of H. indicus offered a significant dose-dependent protection against HFD-induced oxidative stress, as reflected in the levels of catalase, superoxide dismutase, and glutathione peroxidase, which revealed protection against hyperlipidemia and liver damage.
Coenzyme Q homeostasis in aging: response to non-genetic interventions.


Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors.
Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.
  • R. Stocker, V. Bowry, B. Frei
  • Chemistry, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
Investigation of the temporal disappearance of natural antioxidants associated with human low density lipoprotein (LDL) in relation to the appearance of various classes of lipid hydroperoxides shows that ubiquinol-10 is much more efficient in inhibiting LDL oxidation than either lycopene, beta-carotene, or alpha-tocopherol.
Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo.
The faster depletion of LDL ubiquinol and shortened lag time in conjugated diene formation during high-dose lovastatin therapy may, at least partially, be restored with ubiquinone supplementation, but the observed improvement in LDL antioxidative capacity was scarce, and the clinical relevance of ubiquin one supplementation during statin therapy remains open.
[The antioxidant probucol as a regulator of the intensity of free-radical lipid peroxidation processes in the blood of patients with coronary atherosclerosis].
It is evident that antiatherogenic effect of probucol is due to indirect activation of natural defense systems responsible for enzymic detoxication of active oxygen forms and lipoperoxides rather than to direct interaction of this synthetic antioxidant with lipid radicals.
Effect of lipid peroxidation products and antioxidants on the formation of probucol radical in low density lipoproteins.
Effects of antioxidants and products of lipid peroxidation on hemin-induced formation of probucol radical in low density lipoproteins (LDL) from human plasma were studied by EPR-spectroscopy.
Apolipoprotein B-bound lipids as a marker for evaluation of low density lipoprotein oxidation in vivo.
The results suggest that the level of protein-bound lipids may be a marker of LDL oxidation and can be used to evaluate the association of lipoprotein oxidation and atherogenesis.
Antioxidant probucol as an effective scavenger of lipid radicals in low density lipoproteinsin vivo andin vitro
Electron paramagnetic resonance spectrometry data showed that probucol incorporated in vivo into lipoprotein particles interacts with lipid radicals yielding long-lived phenoxyradicals and its dose required for lipop protein protection against atherogenic modification can be decreased to 250 mg/day.
Probucol as an antioxidant and antiatherogenic drug.
Lovastatin decreases coenzyme Q levels in humans.
Data from the three protocols revealed that lovastatin does indeed lower levels of CoQ10, and this reduction would constitute a new risk of cardiac disease, since it is established that Co Q10 is indispensable for cardiac function.