Antioxidants block prostate cancer in lady transgenic mice.

  title={Antioxidants block prostate cancer in lady transgenic mice.},
  author={Vasundara Venkateswaran and Neil E. Fleshner and L. Sugar and Laurence H. Klotz},
  journal={Cancer research},
  volume={64 16},
The development of chemopreventive agents against prostate cancer would benefit from conclusive evidence of their efficacy in animal models that emulate human disease. To date there has been little in vivo evidence supporting their preventive capabilities. The 12T-10 Lady transgenic model spontaneously develops localized prostatic adenocarcinoma and neuroendocrine cancer followed by metastases, recapitulating the natural history of human prostate cancer in many respects. Using male Lady version… CONTINUE READING
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