Antioxidants attenuate the plasma cytokine response to exercise in humans.

  title={Antioxidants attenuate the plasma cytokine response to exercise in humans.},
  author={Theodoros Vassilakopoulos and Maria-Helena Karatza and Paraskevi Katsaounou and Androniki Kollintza and Spyros G. Zakynthinos and Charis Roussos},
  journal={Journal of applied physiology},
  volume={94 3},
Exercise increases plasma TNF-alpha, IL-1beta, and IL-6, yet the stimuli and sources of TNF-alpha and IL-1beta remain largely unknown. We tested the role of oxidative stress and the potential contribution of monocytes in this cytokine (especially IL-1beta) response in previously untrained individuals. Six healthy nonathletes performed two 45-min bicycle exercise sessions at 70% of Vo(2 max) before and after a combination of antioxidants (vitamins E, A, and C for 60 days; allopurinol for 15 days… CONTINUE READING