Antioxidants and the mutagenicity of benzo(a) pyrene and some derivatives.

@article{Calle1978AntioxidantsAT,
  title={Antioxidants and the mutagenicity of benzo(a) pyrene and some derivatives.},
  author={L M Calle and Paul D. Sullivan and Mary D. Nettleman and Ignacio Ocasio and Jack Blazyk and Joseph A. Jollick},
  journal={Biochemical and biophysical research communications},
  year={1978},
  volume={85 1},
  pages={
          351-6
        }
}
Effect of antioxidants on level of gene mutations induced by benz(a)pyrene in mammalian cellsin vitro
TLDR
It has been shown that PAH which are primarily inactive in their physicochemical properties exhibit their mutagenic and carcinogenic potential only as a result of activation by microsomal enzymes and metabolic oxidation in the mammalian body.
Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by butylated hydroxyanisole.
TLDR
BHA appears to inhibit BP-induced pulmonary adenoma formation by inhibiting the amount of the BPDE:DNA adducts formed in lung, and possible mechanisms by which BHA treatment inhibits the formation of BPDe:DNAAdducts are discussed.
Effect of phenolic antioxidants on the mutagenicity of aflatoxin B1
TLDR
The enhancement of mutagenic potency of AFB1 by phenolic antioxidants suggests a specificity with respect to the chemical nature of USAF1, particularly in studies with polycyclic aromatic hydrocarbons.
Review: putative mutagens and carcinogens in foods. III. Butylated hydroxytoluene (BHT).
TLDR
The comutagenic and cocarcinogenic properties of BHT have been demonstrated in tests ranging from the Ames test to cell transformation procedures to in vivo assays, and they are one of the few compounds to have both tumor prophylactic and tumor promoting capacities.
The effects of butylated hydroxytoluene on the in vitro metabolism, DNA-binding and mutagenicity of aflatoxin B1 in the rat.
  • M. Fukayama, D. Hsieh
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1984
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TLDR
It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites.
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TLDR
Benzo(a)pyrene 4,5-oxide was the most mutagenic of the compounds tested in both the bacterial and mammalian systems and was extremely cytotoxic to the V79 cells but had no observable toxicity in the bacterial strains.
Prevention of benzo(a)pyrene‐induced mutagenicity by homogeneous epoxide hydratase
TLDR
It is demonstrated that the metabolic pathway responsible for the mutagenicity of both polycyclic hydrocarbons observed in this system proceeds entirely via an epoxidation pathway and that the responsible metabolites are epoxides or species arising from them.
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TLDR
Four benzo-ring epoxides of the environmental carcinogen benzo(a)pyrene (BP) were tested for mutagenic and cytotoxic activity in 3 strains of Salmonella typhimurium and in Chinese hamster V79 cells.
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A study was initiated to find compounds which have the capacity to induce high levels of activity of microsomal systems detoxifying polycyclic hydrocarbons. Of a large number of chemicals and dietary
Structural requirements for the metabolic activation of benzo[a]pyrene to mutagenic products: effects of modifications in the 4,5-, 7,8-, and 9,10-positions.
TLDR
Evaluation of the intrinsic mutagenic activity of 7,8,9,10-tetrahydrobenzo[a]pyrene 4,5-oxide, benzo[ a]pyrenic 4, 5-oxide and pyrene 4-oxide indicated that saturation or removal of the benzo ring of benzo,[a] pyrene markedly reduces the intrinsicmutagenicity of this K-region arene oxide.
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TLDR
It is suggested that epoxides are the important reactive metabolites responsible for the biological effects of these carcinogens4.
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