Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice.

@article{Harrison2009AntioxidantsAC,
  title={Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice.},
  author={F E Harrison and Johane P Allard and Robert Bixler and C Usoh and Lingyun Li and James Michael May and Michael P. McDonald},
  journal={Nutritional neuroscience},
  year={2009},
  volume={12 5},
  pages={203-18}
}
The present study investigated the relationships among oxidative stress, beta-amyloid and cognitive abilities in the APP/PSEN1 double-transgenic mouse model of Alzheimer's disease. In two experiments, long-term dietary supplements were given to aged APP/PSEN1 mice containing vitamin C alone (1 g/kg diet; Experiment 1) or in combination with a high (750 IU/kg diet, Experiments 1 and 2) or lower (400 IU/kg diet, Experiment 2) dose of vitamin E. Oxidative stress, measured by F(4)-neuroprostanes or… CONTINUE READING

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