Antioxidants Protect Keratinocytes against M. ulcerans Mycolactone Cytotoxicity

  title={Antioxidants Protect Keratinocytes against M. ulcerans Mycolactone Cytotoxicity},
  author={Alvar Gr{\"o}nberg and Louise Zettergren and Kerstin Bergh and Mona St{\aa}hle and Johan Heilborn and Kristian {\"A}ngeby and Pamela L. C. Small and Hannah Akuffo and Sven Britton},
  booktitle={PloS one},
BACKGROUND Mycobacterium ulcerans is the causative agent of necrotizing skin ulcerations in distinctive geographical areas. M. ulcerans produces a macrolide toxin, mycolactone, which has been identified as an important virulence factor in ulcer formation. Mycolactone is cytotoxic to fibroblasts and adipocytes in vitro and has modulating activity on immune cell functions. The effect of mycolactone on keratinocytes has not been reported previously and the mechanism of mycolactone toxicity is… CONTINUE READING


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