Antioxidants Inhibit Monocyte Adhesion by Suppressing Nuclear Factor-icB Mobilization and Induction of Vascular Cell Adhesion Molecule-1 in Endothelial Cells Stimulated to Generate Radicals

Cell adhesion to endothelial cells stimulated by tumor necrosis factor-a (TNF) is due to induction of surface receptors, such as vascular cell adhesion molecule-1 (VCAM-1). The antiaxidant pyrrolidine dithiocarbamate (PDTC) specifically inhibits activation of nuclear factor-KB (NF-KB). Since *B motifs are present in VCAM-1 and intercellular adhesion… CONTINUE READING