Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine

  title={Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine},
  author={Hans Peter Hammes and Alexander Bartmann and Ladina Engel and Petra W{\"u}lfroth},
In order to study the contribution of oxidant stress to the pathogenesis of experimental diabetic retinopathy, male streptozotocin diabetic Lewis rats were treated with the antioxidant and lipid-lowering compound nicanartine (80 mg/kg; n = 8, blood glucose level 16.7 ± 3.9 mmol/l; HbA1 11.8 ± 1.6 %) by oral supplementation for 6 months and compared with untreated diabetic (n = 6; blood glucose 18.1 ± 1.4 mmol/l; HbA1 11.5 ± 1.5 %) and untreated, non-diabetic rats (n = 8; blood glucose 4.0 ± 0.6… CONTINUE READING
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